Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis

Sazan Sartip Abdulhameed; Haween T. Nanakaly

doi:10.15218/zjms.2016.0005

Authors

Sazan Sartip Abdulhameed Department of Periodontology, college of dentistry, Hawler Medical University, Erbil, Iraq.
Haween T. Nanakaly Department of basic sciences, college of dentistry, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.15218/zjms.2016.0005

Keywords:

Chronic periodontitis, Tumor necrosis factor-α, Chlorhexidine mouth wash, Non-surgical periodontal treatment

Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash). Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjects at baseline and four weeks after scaling and root planning treatment were quantified for tumor necrosis factor-α levels using ELISA technique. Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed. Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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